Molecular oxygen is essential for aerobic organisms, and its shortage threatens their survival. Academic field to shift this biological understanding of oxygen is rising as "oxygen biology".
Our own new concept is that cells actively build oxygen concentration area optimal for functions of organs, tissues, and the whole body in oxygen biology.
We intend to research in-depth by what mechanism oxygen remodeling is established to optimize the biological functions.
More specifically, the signaling pathways and oxygen sensing mechanisms are explored from the points of view of energy metabolism in the in vivo hypoxic environment (A01 group). Also, signals mediated by reactive oxygen, nitrogen, sulfur species are studies in the context of physiological responses along with the issue of reversibility of elementary processes respective species control (A02 group).
Also, we will develop imaging technology of reactive molecular species and low-oxygen environment in vivo essential for the performance of the studies above (A03 group).
In addition, as the issues shared by the groups A01-03, we would like to pursue the pathology or abnormality of homeostasis elicited by deviation of the oxygen remodeling.